Constitutive activation of PINK1 protein leads to proteasome-mediated and non-apoptotic cell death independently of mitochondrial autophagy. - 九州大学大学院医学研究院細胞生理学分野

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Constitutive activation of PINK1 protein leads to proteasome-mediated and non-apoptotic cell death independently of mitochondrial autophagy.

Constitutive activation of PINK1 protein leads to proteasome-mediated and non-apoptotic cell death independently of mitochondrial autophagy.
Akabane S, Matsuzaki K, Yamashita S, Arai K, Okatsu K, Kanki T, Matsuda N, Oka T*.
J Biol Chem. 2016; 291(31): 16162-16174.

« Mitophagy is primarily due to alternative autophagy and requires the MAPK1 and MAPK14 signaling pathways. Mitochondrial division occurs concurrently with autophagosome formation but independently of Drp1 during mitophagy. »