研究業績（原著論文）
2026
Mutant-specific dysfunction of RHOBTB2 impairs mitochondrial function and Na+/K+-ATPase levels in a cell model.
Miyamoto S*, Yamashita SI, Belal H, Kato M, Kanki T, Saitsu H*.
Biochim Biophys Acta – Mol Cell Res. 2026 1873(3): 120103.
2025
Transcriptional dynamics uncover the role of BNIP3 in mitophagy during muscle remodeling in Drosophila.
Taoka H, Murakawa T, Kawaguchi K, Koizumi M, Kaminishi T, Sakamaki Y, Tanaka K, Harada A, Inoue K, Kanki T, Ohkawa Y, Fujita N*.
eLife. 2025; 14:RP105834.
The mitophagy receptors BNIP3 and NIX mediate tight attachment and expansion of the isolation membrane to mitochondria.
Yamashita SI, Arai R, Hada H, Padman BS, Lazarou M, Chan DC, Kanki T*, Waguri S*.
J Cell Biol. 2025; 224(7): e202408166.
Mitochondrial fission during mitophagy requires both inner and outer mitofissins.
Furukawa K*, Maruyama T, Yamashita SI, Inoue K, Fukuda T, Noda NN, Kanki T*.
bioRxiv. 2025; DOI: 10.1101/2025.04.13.648642
2024
Comprehensive analysis of non-selective and selective autophagy in yeast atg mutants and characterization of autophagic activity in the absence of the Atg8 conjugation system.
Ginevskaia T, Innokentev A, Furukawa K, Fukuda T, Hayatsu M, Yamashita SI, Inoue K, Shibata S, Kanki T*.
J Biochem. 2024; 176(3): 217-227.
Atg44/Mdi1/mitofissin facilitates Dnm1-mediated mitochondrial fission.
Furukawa K*, Hayatsu M, Okuyama K, Fukuda T, Yamashita SI, Inoue K, Shibata S, Kanki T*.
Autophagy. 2024; 20(10): 2314-2322.
Mitophagy mediated by BNIP3 and NIX protects against ferroptosis by downregulating mitochondrial reactive oxygen species.
Yamashita SI*, Sugiura Y, Matsuoka Y, Maeda R, Inoue K, Furukawa K, Fukuda T, Chan DC, Kanki T*.
Cell Death Differ. 2024; 31(5): 651-661.
Imeglimin mitigates the accumulation of dysfunctional mitochondria to restore insulin secretion and suppress apoptosis of pancreatic β-cells from db/db mice.
Aoyagi K, Nishiwaki C, Nakamichi Y, Yamashita SI, Kanki T, Ohara-Imaizumi M*.
Sci Rep. 2024; 14(1): 6178.
2023
Fission Yeast TORC1 Promotes Cell Proliferation through Sfp1, a Transcription Factor Involved in Ribosome Biogenesis.
Tai YT, Fukuda T*, Morozumi Y, Hirai H, Oda AH, Kamada Y, Akikusa Y, Kanki T, Ohta K, Shiozaki K.
Mol Cell Biol. 2023; 43(12): 675-692.
Neuronal MML-1/MXL-2 regulates systemic aging via glutamate transporter and cell nonautonomous autophagic and peroxidase activity.
Shioda T, Takahashi I, Ikenaka K, Fujita N, Kanki T, Oka T, Mochizuki H, Antebi A, Yoshimori T*, Nakamura S*.
Proc Natl Acad Sci USA. 2023; 120(39): e2221553120.